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Giant Cell Arteritis with Large-Vessel Involvement

Imaging findings

CT shows widespread large-vessel disease with diffuse mural thickening and luminal narrowing of the femoral arteries, conspicuous involvement of the subclavian arteries (irregular, narrowed, thick-walled), and involvement of the carotid and vertebral vessels. After steroid therapy, follow-up shows improvement with more open lumens but residual mural thickening and some scarring/stenosis.

Key takeaways

Giant cell arteritis can involve multiple large arteries with diffuse circumferential mural thickening and luminal narrowing, and this was among the most severe subclavian artery involvement encountered. The clinical diagnosis prompted steroid therapy, with imaging showing partial regression of wall thickening over time while some fibrotic stenosis persists.

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