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Mediastinal Fat Necrosis

Imaging findings

Initial chest radiographs in a patient presenting with acute, localized anterior rib pain reveal a subtle, vague soft tissue opacity in the right anterior cardiophrenic angle. Follow-up chest CT demonstrates a localized area of fat attenuation with surrounding inflammatory stranding and adjacent reactive atelectasis in the low anterior mediastinum, closely mimicking a Morgagni hernia. A follow-up CT scan obtained six months later shows complete resolution of the inflammatory fat stranding and atelectasis, confirming the diagnosis.

Key takeaways

Mediastinal fat necrosis is a benign, self-limiting inflammatory process that occurs due to aseptic necrosis of mediastinal fat, typically presenting with acute, localized pleuritic or chest wall pain. On CT, it presents as an encapsulated fat-density lesion with surrounding inflammatory stranding, often located in the cardiophrenic angles where it can easily be mistaken for an incarcerated diaphragmatic hernia. Demonstrating complete resolution on follow-up imaging confirms the benign nature of this condition and avoids unnecessary surgical exploration.

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