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Extramedullary Hematopoiesis

Imaging findings

Multiple posterior mediastinal masses with fat density intermixed with soft tissue. Associated marked abnormalities in the osseous structures, specifically the ribs and clavicles, in a young patient.

Key takeaways

In patients with conditions like beta thalassemia, compensatory extramedullary hematopoiesis can present as bilateral posterior mediastinal masses. The presence of fat density is a characteristic feature of this marrow-derived process.

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