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Lipomatous Hypertrophy of the Interatrial Septum

Imaging findings

Chest CT shows a large, well-demarcated deposit of fat-attenuation tissue arising from the region of the interatrial septum and extending anteriorly, with normal coronary and mediastinal vessels clearly traversing through the fatty mass.

Key takeaways

Lipomatous hypertrophy of the interatrial septum is a benign, non-encapsulated accumulation of fat that can extend in atypical directions and may be mistaken for a true lipoma or liposarcoma. Because it typically spares the fossa ovalis and allows blood vessels to pass through it without obstruction, it is a benign incidental finding that requires no treatment or intervention.

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