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Invasive Trichosporon Infection in a Transplant Recipient

Imaging findings

A man in his 30s with a heart transplant, on immunosuppression and with prior sternal and other infections, has a month of fevers and dyspnea, right shoulder pain, and skin pustules draining pus. Chest CT shows new rounded nodules at the lung bases resembling formed granulomas. He had a positive cryptococcal antigen titer, but a skin pustule culture grew Trichosporon.

Key takeaways

Trichosporon can cause invasive infection in immunosuppressed transplant patients, presenting with skin pustules/abscesses and pulmonary nodules, and importantly it can cross-react with the cryptococcal antigen assay, which may mislead toward cryptococcosis. Different Trichosporon species are associated with different presentations (skin nodules, pneumonia with nodules), and an association with marijuana smoking has been described.

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