CTICasesAcute Exacerbation of IPF
Imaging findings
Serial chest CTs show a baseline UIP pattern (peripheral, basilar-predominant honeycombing and traction bronchiectasis) progressing to acute respiratory failure with new, diffuse ground-glass opacities and lobular consolidation, consistent with an acute flare of IPF.
Key takeaways
Acute exacerbation of IPF is characterized by rapid clinical deterioration and new ground-glass opacities/consolidation superimposed on a background of chronic fibrosis, representing diffuse alveolar damage (DAD). It carries a high mortality rate.
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