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Osteosarcoma with Metastasis

Imaging findings

Sclerotic/blastic lesion in the femur with periosteal reaction (Codman's triangle). Large, necrotic mass in the chest wall with tumor thrombus in the azygos vein extending into the right atrium.

Key takeaways

Osteosarcoma can metastasize via the venous system, leading to large, invasive tumor thrombi even in the heart.

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