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Anti-MDA5 Positive Interstitial Lung Disease

Imaging findings

Progressive multifocal, multilobar, patchy consolidations and ground-glass opacities that evolve into end-stage lung disease despite treatment.

Key takeaways

Anti-MDA5 antibody-associated ILD is known for rapid, severe progression. It often presents with arthropathy and skin rashes; clinicians should consider this diagnosis in patients with rapidly progressive acute lung injury of unknown etiology.

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