CTICasesACTH-Secreting Bronchial Carcinoid causing Cushing's Syndrome
▶ Watch on YouTube — age-restricted, cannot embed here
Imaging findings
SPECT CT using an indium-111 labeled octreotide scan shows intense, localized radiotracer uptake adjacent to the right heart border. Corresponding high-resolution CT demonstrates a small, smooth, subpleural nodule in the right lower lobe. Histopathological analysis of the resected specimen confirms a typical bronchial carcinoid that stains positive for ACTH, with a micro-metastasis detected in a level 10 lymph node.
Key takeaways
Bronchial carcinoids are neuroendocrine tumors that can occasionally present with paraneoplastic syndromes, such as Cushing's syndrome, secondary to ectopic ACTH secretion. Octreotide scintigraphy is highly sensitive for identifying these somatostatin-receptor-positive tumors, which can be remarkably small and easily overlooked on standard chest CT. Despite their low-grade malignant potential, typical carcinoids can metastasize to regional lymph nodes.
AI-assisted summary — may contain errors. Verify against the source video. Learn more
More from this webinar
- Cocaine-Associated Cardiomyopathy with Hydrostatic Pulmonary EdemaExposure
- Recurrent Spine Osteosarcoma with Pleural MetastasisNeoplastic
- High-Grade Pleomorphic Chest Wall Sarcoma with Pulmonary MetastasesNeoplastic
- Iatrogenic Pulmonary Artery Perforation and Chest Tube MalpositionIatrogenic
- Methotrexate-Induced Iatrogenic Immunodeficiency-Associated Lymphoproliferative DisorderNeoplastic
- Diffuse Alveolar Hemorrhage secondary to Antiphospholipid Antibody SyndromeAutoimmune
- Acute Pulmonary Embolism and Pulmonary Infarction on MRAVascular
- Digital Radiography Artifacts: Grid Misalignment and BackscatterArtifact
See all cases from June 6, 2014 →