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Solitary Fibrous Tumor of the Pleura

Imaging findings

CT chest shows a slowly growing, well-circumscribed, homogeneous pleural-based mass in the left hemithorax followed over a 10-year period. The tumor shows mild internal enhancement on contrast-enhanced CT. Pathology confirmed STAT6 positivity.

Key takeaways

Solitary fibrous tumor of the pleura (SFTP) is a mesenchymal neoplasm arising from the submesothelial connective tissue. It is typically slow-growing and benign, presenting as a large, well-circumscribed pleural mass. Pathological hallmark is STAT6 nuclear staining, resulting from the NAB2-STAT6 gene fusion.

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