CTICasesPulmonary Amyloidosis (AL Type) Presenting as Diffuse Lung Opacities
Imaging findings
Chest radiograph showed extensive polymarginated and confluent opacities. CT revealed diffuse ground-glass opacities, consolidation, and septal thickening throughout the lungs, with some associated circumscribed cystic spaces and small nodules. There was also a small pleural effusion. The appearance initially suggested diffuse adenocarcinoma.
Key takeaways
Pulmonary amyloidosis, particularly the AL type, can present with a dramatic and extensive pattern of ground-glass opacities, consolidation, septal thickening, and cystic spaces, mimicking diffuse adenocarcinoma. The diagnosis should be considered, especially if calcifications are present or light chains are elevated, as confirmed by transbronchial biopsy.
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