CTICasesLymphocytic Interstitial Pneumonia (LIP) in IgA Deficiency
Imaging findings
CT showed bilateral, somewhat peripheral and perilobular areas of consolidation, with underlying architectural distortion suggesting fibrosis. The pattern was relatively symmetric. Small lymph nodes were also noted. Biopsy confirmed Lymphocytic Interstitial Pneumonia (LIP).
Key takeaways
Lymphocytic Interstitial Pneumonia (LIP) can present with a pattern of consolidation, particularly peripheral and perilobular, and may be associated with architectural distortion. While often seen in common variable immunodeficiency (CVID) or other autoimmune conditions, it can also occur in patients with IgA deficiency, sometimes raising the question of GLILD (granulomatous-lymphocytic interstitial lung disease). Recognition of LIP is important as it is a lymphoproliferative disorder.
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