CTICasesAmiodarone-Induced Eosinophilic Pneumonia
Imaging findings
Chest radiograph and CT show bilateral, ground-glass opacities and patchy consolidations with a peripheral and basal predominance. Bronchoalveolar lavage (BAL) fluid analysis reveals a marked eosinophilic inflammatory response, with eosinophils comprising 94% of the total cell count. Follow-up chest radiograph after amiodarone withdrawal and corticosteroid therapy demonstrates complete clearance of the pulmonary abnormalities.
Key takeaways
Amiodarone pulmonary toxicity can manifest as acute or subacute eosinophilic pneumonia, representing a hypersensitivity reaction. Diagnosis is supported by bilateral peripheral ground-glass and consolidative opacities on CT and confirmed by marked eosinophilia (typically >25%) on BAL. This complication is highly responsive to the withdrawal of amiodarone and corticosteroid treatment.
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