CTICasesChronic Granulomatous Disease with Recurrent Pulmonary Infections
Imaging findings
Serial chest CT from 2014 to 2018 in a patient with chronic granulomatous disease shows progressive, extensive pulmonary scarring and consolidative opacities, with airway abnormality including mosaic attenuation and hypoattenuation in the right upper lobe suggesting small-airway involvement, representing the cumulative effect of repeated pulmonary infections over several years.
Key takeaways
The imaging findings alone are nonspecific but become readily explainable once the underlying diagnosis of chronic granulomatous disease, a phagocyte oxidase defect that impairs the ability of white blood cells to kill certain bacteria and fungi, is known. Recurrent infections of this type should prompt consideration of an underlying immunodeficiency such as chronic granulomatous disease or, more commonly, common variable immunodeficiency.
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