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NUT Midline Carcinoma

Imaging findings

A 29-year-old woman presenting with chest pain was found to have near-complete occlusion of the right upper lobe pulmonary artery branch with an associated pulmonary infarct, together with a large mediastinal mass of confluent soft tissue centered near the right hilar lymph node.

Key takeaways

Biopsy showed squamous cell carcinoma that was subsequently confirmed as NUT midline carcinoma by antibody testing and genetic analysis. This rare and very aggressive tumor, typically associated with a survival of around six months, was notable here for the patient surviving about a year, and the presenter noted having now seen two such cases within this conference.

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