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Hypersensitivity Pneumonitis (HP) presenting with emphysema

Imaging findings

Progressive airspace enlargement, cystic changes, and septal thickening in never-smokers. Some cases show features of ground glass opacities and mosaicism, initially mimicking emphysema or fibrotic lung disease.

Key takeaways

Chronic or fibrotic HP can transition to an emphysema-like appearance in a subset of patients, specifically those with antigen sensitivities (e.g., bird ownership).

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