CTICasesMinocycline-Induced Organizing Pneumonia
Imaging findings
A 35-year-old woman with chest pain and cough was referred for CT pulmonary angiography for suspected pulmonary embolism; the requisition noted she had recently started minocycline. CT showed non-segmental peripheral ground-glass opacity and consolidation, most conspicuous in the non-dependent lung, without a classic reverse-halo/atoll sign, along with a few small nodules, findings attributed to minocycline-induced organizing pneumonia given the temporal relationship (started approximately three weeks prior).
Key takeaways
Minocycline is a well-recognized cause of drug-induced organizing pneumonia, and a peripheral, non-dependent, non-segmental ground-glass/consolidative pattern in a patient recently started on the drug should prompt consideration of this diagnosis rather than infection or PE; obtaining a good medication history, as was fortuitously included on this order, is essential to making the connection.
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