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Post-Transplant Lymphoproliferative Disorder (Classical Hodgkin Lymphoma)

Imaging findings

In a young double-lung transplant recipient, serial frontal and lateral chest radiographs over several months show progressive filling-in of the right paratracheal stripe and thickening of the posterior wall of the bronchus intermedius, best appreciated on the lateral view. Corresponding CT shows right paratracheal and subcarinal lymphadenopathy accounting for the radiographic filling-in, with associated soft tissue thickening the posterior wall of the bronchus intermedius.

Key takeaways

Biopsy of the new mediastinal/hilar lymphadenopathy in this transplant recipient was presumed to be post-transplant lymphoproliferative disorder but returned classical Hodgkin lymphoma, EBV-negative, illustrating that Hodgkin lymphoma is a recognized manifestation of PTLD; the case also demonstrates how subtle posterior bronchus-intermedius wall thickening on the lateral radiograph can be the earliest clue to developing lymphadenopathy.

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