CTICasesLipomatous Hypertrophy of the Interatrial Septum with FDG Avidity
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Imaging findings
CT and MRI demonstrate a large area of lipomatous hypertrophy of the interatrial septum, classically sparing the fossa ovalis. This benign finding corresponds to an extremely intense FDG uptake on PET, which was initially concerning for malignancy in a patient with lung cancer.
Key takeaways
Lipomatous hypertrophy of the interatrial septum is a benign condition characterized by excessive fat deposition in the interatrial septum, typically sparing the fossa ovalis. This adipose tissue is often composed of metabolically active brown fat, which can result in intense FDG uptake on PET imaging, leading to false-positive interpretations for malignancy. Recognition of the classic imaging features is crucial to avoid unnecessary invasive procedures.
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