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Melanoma Biopsy Tract Seeding

Imaging findings

CT follow-up in a patient with metastatic melanoma demonstrates a nodule in the right breast that had been biopsied under ultrasound, now showing interval enlargement with new satellite nodules arranged in a curvilinear track along the biopsy needle path, consistent with biopsy tract seeding.

Key takeaways

Biopsy tract seeding (implantation metastasis) is a rare complication occurring in less than 1% of percutaneous biopsies, most frequently reported with mesothelioma and hepatocellular carcinoma but also documented with melanoma and other aggressive malignancies. CT demonstrates new nodules arranged along the needle track in a linear or curvilinear configuration. The diagnosis should be considered when new nodules appear in the expected biopsy path.

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