CTICasesPulmonary Lymphedema secondary to Sarcoid-like Lymphadenopathy (Humira-Induced)
Imaging findings
CT in a 38-year-old man shows extensive, crisply margined sarcoid-like hilar and mediastinal lymphadenopathy associated with diffuse ground-glass opacity, prominent septal lines, and a subpleural fluid-like margin (lymphedema). The lymphadenopathy and lung disease significantly regressed after taking the patient off adalimumab (Humira) and starting corticosteroids.
Key takeaways
Tumor necrosis factor (TNF) inhibitors like adalimumab (Humira) can paradoxically induce sarcoid-like granulomatous reactions. Large, well-defined lymph nodes can obstruct lymphatic drainage, presenting as pulmonary lymphedema with prominent septal lines and ground-glass opacities, which is reversible with steroids and drug discontinuation.
AI-assisted summary — may contain errors. Verify against the source video. Learn more
More from this webinar
- Niemann-Pick DiseaseMetabolic
- Diffuse Invasive Mucinous AdenocarcinomaNeoplastic
- Congenital Pulmonary Atresia with Glenn and Potts Shunts and RV-Dependent Coronary CirculationCongenital
- Bacillus cereus PneumoniaInfection
- Giant Ascending Aortic Aneurysm and Chronic Type A DissectionVascular
- Veno-Arterial ECMO Flow PatternsIatrogenic
- Cytomegalovirus PneumonitisInfection
- Esophageal Duplication CystCongenital
See all cases from April 9, 2021 →
Related Iatrogenic cases
- Iatrogenic Pulmonary Infarction after Metastasectomy
- Iatrogenic Left Hemidiaphragm Injury with Gastrothorax
- Infected Endovascular Stent Graft (Gas in Excluded Aortic False Lumen)
- Alpha-1 Antitrypsin Deficiency treated with Endobronchial Valve Lung Volume Reduction
- Acute Lung Allograft Rejection
- Chronic Lung Allograft Rejection: Upper Lobe Scarring Pattern