CTICasesCrystal-Storing Histiocytoma
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Imaging findings
A chest x-ray revealed a nodule, later confirmed on CT as a well-speculated nodule with surrounding pleural abnormality (pleural tail sign). PET imaging showed indeterminate activity for malignancy.
Key takeaways
Crystal-storing histiocytoma is a rare, benign histiocytic disorder characterized by histiocytes storing crystallized immunoglobulins. It typically presents as a lung nodule and can mimic malignancy, including on PET imaging. While often associated with lymphoproliferative diseases or multiple myeloma, it has been reported in patients without such conditions, particularly those with rheumatoid arthritis and a positive rheumatoid factor.
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