CTICasesLupus-Related Lung Disease Evolving to a UIP-like Pattern
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Imaging findings
Areas of cystic confluence with thin to moderately thick walls, alongside consolidation and ground glass, suggesting an active lung process (NSIP or organizing pneumonia) with lung destruction. Follow-up showed larger, confluent thick-walled cysts and angulated island-like areas of lung destruction, which could be confused with a UIP pattern. However, subpleural sparing was present.
Key takeaways
This case further illustrates the diverse and evolving patterns of lupus-related lung disease, which can develop into a appearance mimicking UIP but remains distinct due to features like subpleural sparing. The exact pathogenesis (e.g., follicular bronchiolitis, organizing pneumonia, NSIP) leading to this form of lung destruction remains a subject of discussion.
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