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Pulmonary Arterial Hypertension with In-situ Thrombus

Imaging findings

CT chest shows a massively dilated main pulmonary artery and a non-obstructive, layering intimal thrombus in the lobar and segmental branches. No acute pulmonary emboli or systemic deep venous thrombosis source was present. Lung pathology post-transplant confirmed idiopathic pulmonary arterial hypertension.

Key takeaways

In patients with severe, long-standing pulmonary arterial hypertension (PAH), stagnant blood flow and endothelial dysfunction can lead to in-situ thrombosis in the dilated central and segmental pulmonary arteries. This can mimic chronic thromboembolic disease (CTEPH) and requires careful clinical differentiation.

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