CTICasesPulmonary Alveolar Proteinosis
Imaging findings
CT chest demonstrates diffuse, symmetric ground-glass opacities with superimposed interlobular septal thickening (crazy-paving pattern) in a patient in their 80s. Bronchoalveolar lavage confirmed pulmonary alveolar proteinosis, and subsequent therapeutic lavage was complicated by respiratory failure.
Key takeaways
Pulmonary alveolar proteinosis (PAP) is characterized by the accumulation of surfactant in alveoli. While most cases are autoimmune (associated with anti-GM-CSF antibodies) and present in middle-aged adults, PAP can present in elderly patients and carries a high risk of procedure-related complications during whole-lung lavage.
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