CTICasesRadiation-Induced Malignant Peripheral Nerve Sheath Tumor (MPNST) of the Apex
Imaging findings
Chest radiograph/scout view and CT show a firm, inhomogeneous mass in the left apex that has high FDG uptake on PET CT, arising in the previous radiation field for childhood Hodgkin lymphoma.
Key takeaways
Radiation-induced sarcomas, such as MPNSTs, can arise in previous radiation fields (e.g., post-Hodgkin lymphoma therapy). While typically described as developing around 7 years or decades post-radiation, they can occur after variable latencies and should be considered in the differential of a new apical or chest wall mass within a radiation portal.
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