CTICasesAdenocarcinoma arising in Anti-Synthetase Syndrome Fibrosis
Imaging findings
CT chest shows a baseline NSIP/organizing pneumonia pattern of basal predominant fibrosis in a patient with anti-synthetase syndrome. A solid, peripheral mass is present in the right upper lobe, which shows high FDG uptake on PET CT and was proven to be adenocarcinoma.
Key takeaways
Anti-synthetase syndrome is an autoimmune disease that frequently causes interstitial lung disease (often a mixed NSIP-OP pattern). Chronic interstitial inflammation and fibrosis are known risk factors for developing lung cancer, typically adenocarcinoma, which can arise away from or within the fibrotic regions.
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