CTICasesAmyloid Cysts in Medullary Thyroid Cancer
Imaging findings
CT chest shows multiple, small, thin-walled pulmonary cysts and nodules in a 40-year-old female. Neck CT shows a large thyroid mass, and laboratory testing shows calcitonin levels of 35,000 pg/mL, diagnostic of medullary thyroid carcinoma.
Key takeaways
Medullary thyroid cancer produces calcitonin, which can deposit in tissues as amyloid. In the lungs, calcitonin-derived amyloid deposition can lead to the formation of localized amyloidomas and thin-walled pulmonary cysts, which should not be confused with treated metastases or lymphangioleiomyomatosis (LAM).
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