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Adenoid Cystic Carcinoma Pulmonary Metastases with Target Ring Appearance

Imaging findings

CT in a woman with prior head and neck adenoid cystic carcinoma demonstrates multiple bilateral pulmonary nodules with a striking morphology: several nodules show a target-like or double-ring appearance with concentric rims of soft tissue attenuation surrounding a central soft tissue core, distinct from the subsolid nodules seen on the prior PET-CT two years earlier, which have slowly enlarged over the interval.

Key takeaways

Adenoid cystic carcinoma (ACC) is a salivary gland-type malignancy notorious for late and indolent pulmonary metastases that may not be FDG-avid on PET and grow over years to decades. Pulmonary metastases from ACC can have an unusual spoke-wheel or target ring morphology that should be distinguished from primary pulmonary adenocarcinoma. When multiple slow-growing pulmonary nodules with unusual morphology are encountered in a patient with head and neck ACC, metastatic disease should take priority in the differential.

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