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Paradoxical Embolism in Transit and Systemic Arterial Occlusion via a Patent Foramen Ovale

Paradoxical Embolism in Transit and Systemic Arterial Occlusion via a Patent Foramen Ovale▶ Watch on YouTube — age-restricted, cannot embed here

Imaging findings

CT pulmonary angiogram demonstrates large, bilateral pulmonary emboli. Additionally, there is a large, mobile, worm-like filling defect within the ascending aorta that extends into the innominate, right subclavian, and left common carotid arteries, with the latter being almost completely occluded. The patient subsequently developed multiple cerebral infarctions.

Key takeaways

Paradoxical embolization occurs when a venous thrombus bypasses the pulmonary circulation via a right-to-left shunt, most commonly a patent foramen ovale (PFO), and enters the systemic arterial circulation. The PFO often opens or widens due to acutely elevated right-sided heart pressures from a large pulmonary embolism. This can result in devastating systemic arterial occlusion, including strokes.

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