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Pulmonary Artery Thrombus mimicking Sarcoma

Imaging findings

CT chest shows a large, mass-like filling defect in the main and branch pulmonary arteries extending down to the pulmonic valve, which grew over six years despite anticoagulation. Surgical resection and autopsy confirmed it was entirely chronic thrombus (CTEPH).

Key takeaways

Chronic thromboembolic pulmonary hypertension (CTEPH) can present with massive in situ or chronic thrombi that fill the main pulmonary artery. This appearance can be virtually indistinguishable from a pulmonary artery sarcoma. Pathological examination of the resected specimen is critical to exclude malignancy.

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