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Reactive Lymphadenopathy in COVID-19 Pneumonia

Imaging findings

CT chest in a patient with acute COVID-19 pneumonia demonstrates progression of bilateral peripheral consolidations and ground-glass opacities, accompanied by the rapid development of mild, generalized hilar and mediastinal lymphadenopathy over a 2-day period.

Key takeaways

While lymphadenopathy is relatively uncommon in typical COVID-19 infection, severe cases can show rapid development of reactive mediastinal and hilar lymph node enlargement. This represents a normal inflammatory response and should not be mistaken for lymphoma, sarcoidosis, or secondary bacterial superinfection.

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