CTICasesPulmonary Cryptococcosis Mimicking Metastatic Disease
Imaging findings
CT chest in a patient with vocal cord squamous cell carcinoma shows new, multiple, peripheral pulmonary nodules with fuzzy margins and surrounding ground-glass halos, predominantly in the right upper lobe. Serum Cryptococcus antigen was positive, and lesions resolved with antifungal therapy.
Key takeaways
Pulmonary Cryptococcosis is an opportunistic fungal infection that can also occur in immunocompetent hosts. In oncologic patients, cryptococcal nodules with surrounding halo signs can mimic hematogenous metastatic disease. Serum antigen testing or biopsy is necessary to differentiate the two and avoid staging errors.
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