CTICasesAnti-PL-7 Antisynthetase Syndrome
Imaging findings
An older woman presents with fairly symmetric lower lung zone opacity on radiograph with possible small effusions, and CT shows dilated airways with traction bronchiectasis and a lower lobe-predominant consolidation pattern similar to the preceding anti-Jo-1 case.
Key takeaways
Antisynthetase antibody testing was positive for anti-PL-7 rather than anti-Jo-1, the most common antisynthetase antibody, and these antibodies tend to be mutually exclusive so typically only one is positive; the patient later developed a rash and myositis. Even after treatment and partial improvement of the consolidation, the basal-predominant traction bronchiectasis persisted, illustrating that fibrotic change from antisynthetase-syndrome ILD can be only partially reversible.
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