CTICasesSolitary Pulmonary Amyloidoma
Imaging findings
A left lower lobe pulmonary nodule with central calcification, absent in 2008 but new by 2014, grew substantially between 2014 and 2017 while the calcified focus remained stable; PET showed only minimal metabolic activity (SUV less than 2), and the nodule was resected as the only lung abnormality.
Key takeaways
Pathology confirmed amyloid deposition, an amyloidoma, rather than the reactivation granuloma or calcified adenocarcinoma that were considered given the new, slowly growing, centrally calcified appearance; large solitary amyloid nodules tend to occur in the lower lung zones, can be surrounded by emphysema, and the associated calcification is more often ossification than dystrophic calcium. This was regarded as more of a diagnostic curiosity than a case with strong clinical implications, since it was an isolated finding without a clear cause for local amyloid deposition.
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