CTICasesDisseminated Histoplasmosis
Imaging findings
Radiograph of a young, asymptomatic adult shows multiple conspicuous, tiny, randomly distributed calcified nodules with a basal predominance.
Key takeaways
Conspicuous, calcified miliary nodules in an asymptomatic patient from an endemic region (like the Midwest) are a classic presentation of old, healed disseminated histoplasmosis. They should not be confused with active pneumoconiosis (like silicosis) on occupational screening, which typically shows upper-lung predominant, non-calcified nodules. Varicella pneumonia is another historical cause of small calcified nodules.
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