CTICasesWaldenström Macroglobulinemia Associated Pulmonary Amyloidosis and Cystic Lung Disease
Imaging findings
High-resolution chest CT shows chronic, bilateral, multi-lobar cystic spaces of variable sizes, some with internal tissue elements. Over time, the patient developed two parenchymal nodular opacities containing tiny internal foci of calcification or bone on bone window settings.
Key takeaways
Cystic lung disease can develop secondary to light chain or protein deposition in the pulmonary parenchyma. This condition is strongly associated with lymphoplasmacytic proliferative disorders, such as Waldenström macroglobulinemia or Sjögren's syndrome, where the deposition can also form nodular amyloidomas that may slowly calcify or ossify over time.
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