CTICasesSpontaneous Regression of Metastases in Non-Small Cell Lung Carcinoma
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Imaging findings
Initial chest CT from August demonstrates a right apical pulmonary nodule, a second pulmonary nodule, abnormal nodular pleural thickening, a left pleural effusion, and soft tissue thickening in the apex with subtle erosion of the adjacent rib. A follow-up CT scan from December reveals that all intrapulmonary and pleural lesions have spontaneously decreased in size without any interval therapy. However, the apical soft tissue lesion with rib invasion has progressed. Biopsy of the rib lesion confirmed non-small cell lung carcinoma.
Key takeaways
Non-small cell lung carcinoma can occasionally present with discordant clinical behavior, including the spontaneous regression or shrinkage of metastatic pleural and intrapulmonary nodules in the absence of treatment, while the primary site of tumor invasion continues to progress. Spontaneous regression of metastases is a rare phenomenon and can lead to initial diagnostic confusion.
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