CTICasesMediastinal Liposarcoma
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Imaging findings
Chest radiographs and CT reveal a very large fat-containing mediastinal mass in the middle and posterior mediastinum with internal soft tissue components, including thick, irregular linear septations. Pathological analysis of the resected specimen confirmed a well-differentiated liposarcoma.
Key takeaways
Well-differentiated liposarcomas can arise in the mediastinum and mimic benign lipomas. Pathologists utilize MDM2 gene amplification testing to reliably distinguish well-differentiated liposarcomas from benign lipomatous tumors.
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