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Post-operative Permeability Pulmonary Edema / Fat Embolism Syndrome

Imaging findings

Chest radiographs taken over two days following a cervical spine discectomy and fusion demonstrate a rapid onset of bilateral, symmetric, predominantly perihilar opacities without pleural effusions or cardiomegaly. A subsequent CT angiogram shows a diffuse crazy-paving pattern and ground-glass opacities with subpleural sparing. A follow-up CT obtained four days later shows rapid clearance of the parenchymal opacities with mild residual bronchial dilation and perilobular thickening.

Key takeaways

Rapidly developing, symmetric ground-glass opacities following major spine surgery can represent non-cardiogenic permeability edema or a mild, self-limited form of fat embolism syndrome. Extensive spine surgery involving vertebral body instrumentation and pedicle screw placement can mobilize marrow fat into the systemic venous circulation, causing alveolar-capillary barrier injury and permeability edema that typically resolves quickly with supportive care.

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