CTICasesLangerhans Cell Histiocytosis
Imaging findings
CT chest in a heavy smoker shows numerous centrilobular nodules of varying sizes, primarily distributed in the upper and middle lung zones, appearing shortly after undergoing chemotherapy for an extrapulmonary squamous cell carcinoma.
Key takeaways
Pulmonary Langerhans cell histiocytosis (PLCH) is a smoking-related interstitial lung disease. It can manifest during or after chemotherapy (potentially triggered by alveolar macrophage changes or smoking resumption), presenting as centrilobular nodules and bizarrely shaped cysts that can mimic pulmonary metastases.
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