Cryptococcus Pulmonary Nodule in CVID
Imaging findings
CT chest shows a vague, solid nodule in the left apex, which has remained persistent over several weeks, associated with minimal surrounding reactive changes. The patient had common variable immunodeficiency (CVID) and biopsy confirmed Cryptococcus infection.
Key takeaways
Common variable immunodeficiency (CVID) predisposes patients to atypical infections. Cryptococcus neoformans can present as a solitary, stable pulmonary nodule, mimicking primary lung cancer. In CVID patients, tissue biopsy or direct antigen testing is essential for diagnosis as serology can be false-negative.
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