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Pulmonary Xanthogranulomatous Inflammation

Imaging findings

A contrast-enhanced chest CT demonstrates a newly developed, thick-walled cavitary mass in the right upper lobe of a liver and kidney transplant patient with a history of Klebsiella urinary tract sepsis.

Key takeaways

Xanthogranulomatous inflammation is a chronic, benign inflammatory process characterized by an abundance of lipid-laden macrophages and Touton giant cells. Although most commonly seen in the kidneys or gallbladder, xanthogranulomatous disease can rarely occur in the lungs, typically as a walled-off, chronic inflammatory reaction triggered by recurrent or persistent bacterial infections such as Klebsiella.

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