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Isocyanate-Induced Pneumonitis

Imaging findings

CT chest shows bilateral, symmetric ground-glass opacities and consolidations in an organizing pneumonia pattern with crazy paving, predominantly in the upper lobes, showing rapid improvement after corticosteroid therapy.

Key takeaways

Inhalation of heated polyurethane or isocyanate vapors (e.g., during drilling or welding plastic-coated metals) can cause acute chemical pneumonitis or hypersensitivity pneumonitis. Patients present with acute lung injury that typically responds rapidly to steroids and avoidance of the offending exposure.

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