CTICasesSarcoid-Like Reaction in Patient on Pirfenidone for IPF
[...]. Sarcoid-Like Reaction in Patient on Pirfenidone for IPF. CTICases. Published August 12, 2016. https://cticases.com/c/386b5
Imaging findings
Bulky, metabolically active lymphadenopathy is observed in the mediastinum, upper abdomen, and supraclavicular regions, superimposed on fibrosing interstitial lung disease (UIP/IPF pattern). Excisional biopsy revealed non-necrotizing granulomas.
Key takeaways
The development of widespread granulomatous lymphadenopathy in a patient with IPF on pirfenidone, despite pirfenidone not being a known cause of sarcoid-like reactions, poses a diagnostic challenge. It raises questions about whether it's an unrecognized drug effect, true sarcoidosis, or an unmasking of an underlying immune response.
AI-assisted summary — may contain errors. Verify against the source video. Learn more
More from this webinar
- Primary Pulmonary LymphomaNeoplastic
- Metastatic Pulmonary Calcification in Chronic Renal DiseaseMetabolic
- Persistent Aorto-Caval Fistula Post-Trans-Caval TAVIIatrogenic
- Aortic Dissection with Endograft Collapse and Distal OcclusionVascular
- Hemi-Azygos Continuation of IVC with Left SVC and Mediastinal CystCongenital
- Cardiac HemochromatosisMetabolic
- Leukemic Infiltration of Myocardium and PericardiumNeoplastic
- Atherosclerotic Right Coronary Artery AneurysmVascular
See all cases from August 12, 2016 →
Related Inflammatory cases
- Acquired Left Lower Lobe Bronchial Angulation and Recurrent Aspiration
- End-stage Langerhans Cell Histiocytosis (LCH) with Severe Pulmonary Hypertension
- Mediastinal/Epicardial Nodular Fat Necrosis (or Necrosed Lipoma)
- Inflammatory Myofibroblastic Tumor (Inflammatory Pseudotumor)
- Diffuse Alveolar Hemorrhage (DAH) post-Donor Lymphocyte Infusion
- Latissimus Dorsi Bursitis