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Post-transplant lymphoproliferative disorder (PTLD) after stem cell transplantation

Imaging findings

CT scan shows multiple solid, smooth, pulmonary nodules with air bronchograms in a basally predominant distribution. The patient also had low-attenuation lesions in the brain and liver, and CSF analysis confirmed a clonal population of abnormal lymphocytes, diagnostic of PTLD.

Key takeaways

PTLD is a well-known complication of stem cell or solid organ transplantation under drug-induced immunosuppression, typically driven by EBV reactivation. Pulmonary manifestations include solid nodules that can mimic fungal infections like invasive aspergillosis.

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