CTICasesMyeloid Sarcoma (Chloroma) of the Manubrium
Imaging findings
Sagittal and axial CT scans demonstrate rapid progression of a highly destructive, osteolytic bone lesion of the manubrium with an associated large, soft-tissue mass extending into the anterior mediastinum and chest wall. The patient had a history of chronic myelogenous leukemia (CML) in acute blast crisis.
Key takeaways
Myeloid sarcoma, historically termed chloroma, is an extramedullary tumor-like collection of immature granulocytic cells associated with myelogenous leukemias. It can occur in patients with AML, CML, or myelodysplastic syndromes, often heralding a blast crisis. Sternal or manubrial destruction is a recognized thoracic presentation that typically responds well to localized palliative radiotherapy or systemic chemotherapy.
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