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Langerhans Cell Histiocytosis

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Imaging findings

The patient, a heart transplant recipient, showed extensive lung disease characterized by numerous nodules and cystic changes in the mid and upper lungs. Despite the unusual presentation and large size of some nodules, biopsy confirmed Langerhans cell histiocytosis. The patient was also a daily marijuana smoker, which was speculated to be a possible trigger.

Key takeaways

Langerhans cell histiocytosis should be considered in patients with cystic lung disease, even when nodules appear larger or more confluent than typical presentations. A history of smoking, including marijuana, may be a relevant factor in the etiology.

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