CTICasesPulmonary Toxoplasmosis (Diffuse Ground-Glass) in a Stem Cell Transplant Recipient
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Imaging findings
A chest radiograph initially showed very vague diffuse lung disease. CT scan demonstrated a fairly uniform, low-grade diffuse ground-glass abnormality extending from the lung apices down to the bases, with only a few slightly denser patches. A follow-up CT five days later showed worsening of the disease, with more pronounced and somewhat denser ground-glass opacities, particularly around the airways.
Key takeaways
This case further illustrates pulmonary toxoplasmosis as a cause of diffuse lung disease in stem cell transplant recipients. The presentation can be subtle, with diffuse low-grade ground-glass opacities that may progress rapidly. In immunocompromised patients with diffuse pulmonary infiltrates, toxoplasmosis should be considered alongside more common etiologies like viral infections and Pneumocystis pneumonia. Definitive diagnosis in this case was made by lavage.
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