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Chronic Progressive Pulmonary Blastomycosis with Cavitary Disease and Bronchiectasis

Chronic Progressive Pulmonary Blastomycosis with Cavitary Disease and Bronchiectasis▶ Watch on YouTube — age-restricted, cannot embed here

Imaging findings

Initial radiographs and CT from 2012 show mass-like consolidation, significant volume loss in the upper lobes, emphysema, and dilated airways predominantly in the upper lobes. Follow-up radiographs and CT two years later demonstrate dramatic progression with severe bronchiectasis, extensive cavitary disease, spread of disease to the lower lobes, and fluid-filled cavities.

Key takeaways

Blastomycosis can present as a chronic, progressive lung infection leading to severe tissue destruction, cavitary disease, and bronchiectasis if left untreated, mimicking tuberculosis. Untreated cases, even initially mild-to-moderate, can evolve dramatically and may require aggressive therapy like amphotericin.

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